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Mission

We will focus our experimental and modelling efforts on the energy stress response network in mouse and human patient  cells, tissues and at the whole organism level.  Multidisciplinairy approaches with state-of-the-art technologies will be used for modelling of the direct relationship between processes for ATP production and distribution and ATP expenditure, both under physiological conditions and following disease-related environmental or genetic pertubations. The developed physiological and energy stress response models will be used to improve the energy status of man in health and disease via pharmacological and nutritional interventions.