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Model Validation

Model validation, refinement and application
(WP3 leader Frans Russel and Jan Smeitink) 

This WP will assess the predictive power of the models developed in the iterative process between WP1 and WP2 by testing the predicted beneficial effects of drugs and nutraceuticals under normal and disease conditions. It will also be determined whether the in silico predictions allow pinpointing of adverse off-target effects of registered classes of pharmaceuticals. Predicted biomarkers delivered by the top-down and bottom-up approaches (WP1) will be validated by applying the experimental strategies described in WP2 to generate read-outs, at the various levels of complexity, and at various (sub)cellular concentrations of drugs/nutraceuticals of interest.